HumanAtherosclerosis and the Diet. High cholesterol can slow pelvic blood flow. The hormone that causes a cholesterol "age gap" between men and women is estrogen. Cholesterol Fact or Fiction. Kidney disease, alcoholism, high protein diets. Furthermore, even if high cholesterol does not run in your family, you can still develop it. Diets with too much saturated fat, trans fat, and cholesterol are the. The straight dope on cholesterol – Part I - I’ve been planning to write at length about this topic for a few months, but I’ve been hesitant to do so for several reasons: To discuss it properly requires great care and attention (mine and yours, respectively). My own education on this topic only really began about 9 months ago, and I’m still learning from my mentors at a geometric pace. This topic can’t be covered in one post, even a Peter- Attia- who- can’t- seem- to- say- anything- under- 2,0. I feel a bit like an imposter writing about lipidology because my mentors on this topic (below) have already addressed this topic so well, I’m not sure I have anything to add. But here’s the thing. Bill Cromwell, and Dr. I am eternally in their debt and see it as my duty to pass this information on to everyone interested. Are you ready to start an exciting journey? Concept #1 – What is cholesterol? Cholesterol is a 2. Each line in this figure represents a bond between two carbon atoms. In a subsequent post I will write about a cousin of cholesterol called phytosterol, but at this time I think the introduction would only confuse matters. Cholesterol is required by all cell membranes and to produce steroid hormones and bile acids. Of this “made” or “synthesized” cholesterol, our liver synthesizes about 2. Plasma cholesterol levels (which is what clinicians measure with standard cholesterol tests) often have little to do with cellular cholesterol, especially artery cholesterol, which is what we really care about. For example, when cholesterol intake is decreased, the body will synthesize more cholesterol and/or absorb (i. The way our body absorbs cholesterol is so amazing, so I want to spend a bit of time discussing it. In medical school, whenever we had to study physiology or pathology I always had a tendency to want to anthropomorphize everything. It’s just how my brain works, I guess, and understanding cholesterol absorption is a great example of this sort of thinking. The enterocyte has “sterol- excess sensors” (a nuclear transcription factor called LXR) that do the monitoring and these sensors activate the genes that regulate NPC1. L1 and ABCG5,G8). There is another nuance to this, which is where the CE versus UC distinction comes in: Only free or unesterified cholesterol (UC) can be absorbed through gut enterocytes. So, if the liver is going to excrete CE into bile and ultimately the gut, it needs to de- esterify it using enzymes called cholesterol esterolases which can convert liver CE to UC. Also realize that the number one way for the liver to rid itself of cholesterol is to convert the cholesterol into a bile acid, efflux that to the bile (via a transporter called ABCB1. Concept #3 – Is cholesterol bad? GM Diet Plan To Lose Weight In 7 Days. GENERAL FAQ’s RELATED TO GM.One of the biggest misconceptions out there (maybe second only to the idea that eating fat makes you fat) is that cholesterol is “bad.” This could not be further from the truth. Every cell in our body is surrounded by a membrane. Version of the GM Diet. GM Diet vegetarian is a popular. How can you lower high cholesterol? Fiber and Cholesterol Keep Your Heart Healthy & Control Cholesterol with Food First. To lower LDL, try eating more foods high in soluble fiber. Care guide for 2 Gram Sodium Diet. Includes: possible causes, signs and symptoms. The goal of a 2 gram sodium diet is to prevent or lower high blood pressure. Cholesterol is one of the main building blocks used to make cell membranes (in particular, the ever- important “lipid bilayer” of the cell membrane). Beyond cholesterol’s role in allowing cells to even exist, it also serves an important role in the synthesis of vitamins and steroid hormones, including sex hormones and bile acids. If this comparison doesn’t convince you of the vital importance of cholesterol, nothing I say will. One of the unfortunate results of the eternal need to simplify everything is that we (i. When one measures cholesterol in the blood – we really do not know the final destination of those cholesterol molecules! And that’s where we’ll pick it up next time – how does “good” cholesterol end up in places it doesn’t belong and cause “bad” problems? It’s designed primarily for physicians, but I suspect many of you out there will find it helpful, if not now, certainly once we’re done with this series. To summarize this somewhat complex issue. Cholesterol is “just” another fancy organic molecule in our body, but with an interesting distinction: we eat it, we make it, we store it, and we excrete it – all in different amounts. The pool of cholesterol in our body is essential for life. The reason is it not only has to be de- esterified, but it competes for absorption with the vastly larger amounts of UC supplied by the biliary route. Re- absorption of the cholesterol we synthesize in our body is the dominant source of the cholesterol in our body. That is, most of the cholesterol in our body was made by our body. The process of regulating cholesterol is very complex and multifaceted with multiple layers of control. You will discover that synthesis and absorption are very interrelated. Eating cholesterol has very little impact on the cholesterol levels in your body. This is a fact, not my opinion. Years ago the Canadian Guidelines removed the limitation of dietary cholesterol. The rest of the world, especially the United States, needs to catch up.(To Part II »)2.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
June 2017
Categories |